Germline Exposures
  • Home
  • Expert Q&A
    • Eva Jablonka Q&A
    • Amander Clark Q&A
    • Mirella Meyer-Ficca Q&A
    • Janine LaSalle Q&A
    • Dana Dolinoy Q&A
    • Ben Laufer Q&A
    • Tracy Bale Q&A
    • Susan Murphy Q&A
    • Alycia Halladay Q&A
    • Wendy Chung Q&A
    • Pradeep Bhide Q&A
    • Pat Hunt Q&A
    • Yauk and Marchetti Q&A
    • Emilie Rissman Q&A
    • Carol Kwiatkowski Q&A
    • Linda Birnbaum Q&A
    • Virender Rehan Q&A
    • Carlos Guerrero-Bosagna Q&A
    • Randy Jirtle Q&A
    • Jerry Heindel Q&A
    • Cheryl Walker Q&A
    • Eileen McLaughlin Q&A
    • Carmen Marsit Q&A
    • Marisa Bartolomei Q&A
    • Christopher Gregg Q&A
    • Andrea Baccarelli Q&A
    • David Moore Q&A
    • Patrick Allard Q&A
    • Catherine Dulac Q&A
    • Lucas Argueso Q&A
    • Toshi Shioda Q&A
    • Miklos Toth Q&A
    • Piroska Szabo Q&A
    • Reinisch Q&A
    • Klebanoff Q&A
    • Denis Noble Q&A
  • Germline in the News
  • Science
    • Studies of Interest
    • Escher Prize
    • Grants
    • Smoking Workshop
    • Webinar Series
    • Parent Survey
  • Presentations
  • About Us
    • Contact
    • Join our Email List
    • Jill Escher Q&A
  • Blog

Study Finds Aberrant Epigenome in Autism Dad Sperm; Imprinted Genes Implicated

5/2/2015

0 Comments

 
SNORD115 regions were represented in 4 of the top 10 DMRs.Dani Fallin and Andrew Feinberg of John Hopkins University Center for Epigenetics, and colleagues, have found a DNA methylation pattern in the sperm of fathers with an increased risk of fathering autistic children that is also present in brains of unrelated autistic children. See the paper at the International Journal of Epidemiology, April 2015.

Looking at the sperm of fathers of young children considered at risk for autism, the team found 193 significant differentially methylated regions (DMRs), compared to controls; those sperm DMRs are large stretches of dozens of CpGs, not single CpG sites, and were consistent with 75 CpG probes from the 450K; and the DMRs are involved in developmental processes including imprinting disorders

The aberrant methylation was associated with genomic areas involved in the  imprinting disorders Angelman syndrome and Prader-Wili Syndrome. The region regulates neuron growth and produces important regulatory molecules. The large-scale methylation differences suggests epigenetic deviations in the germline may manifest as abnormalities in early brain development of offspring, producing the autism phenotype.


0 Comments

Your comment will be posted after it is approved.


Leave a Reply.

    Author

    Jill Escher, Escher Fund for Autism, is a California-based science philanthropist and mother of two children with severe autism, focused on the question of how environmentally induced germline disruptions may be contributing to today's epidemics of neurodevelopmental impairment. You can read about her discovery of her intensive prenatal exposure to synthetic hormone drugs here. Jill is also president of Autism Society San Francisco Bay Area.

    Archives

    July 2021
    June 2019
    April 2019
    January 2019
    December 2018
    November 2018
    July 2018
    February 2018
    June 2017
    April 2017
    February 2017
    January 2017
    October 2016
    September 2016
    May 2016
    April 2016
    March 2016
    February 2016
    October 2015
    August 2015
    July 2015
    June 2015
    May 2015
    April 2015
    March 2015
    February 2015
    January 2015
    December 2014

    Categories

    All

    RSS Feed

Proudly powered by Weebly
  • Home
  • Expert Q&A
    • Eva Jablonka Q&A
    • Amander Clark Q&A
    • Mirella Meyer-Ficca Q&A
    • Janine LaSalle Q&A
    • Dana Dolinoy Q&A
    • Ben Laufer Q&A
    • Tracy Bale Q&A
    • Susan Murphy Q&A
    • Alycia Halladay Q&A
    • Wendy Chung Q&A
    • Pradeep Bhide Q&A
    • Pat Hunt Q&A
    • Yauk and Marchetti Q&A
    • Emilie Rissman Q&A
    • Carol Kwiatkowski Q&A
    • Linda Birnbaum Q&A
    • Virender Rehan Q&A
    • Carlos Guerrero-Bosagna Q&A
    • Randy Jirtle Q&A
    • Jerry Heindel Q&A
    • Cheryl Walker Q&A
    • Eileen McLaughlin Q&A
    • Carmen Marsit Q&A
    • Marisa Bartolomei Q&A
    • Christopher Gregg Q&A
    • Andrea Baccarelli Q&A
    • David Moore Q&A
    • Patrick Allard Q&A
    • Catherine Dulac Q&A
    • Lucas Argueso Q&A
    • Toshi Shioda Q&A
    • Miklos Toth Q&A
    • Piroska Szabo Q&A
    • Reinisch Q&A
    • Klebanoff Q&A
    • Denis Noble Q&A
  • Germline in the News
  • Science
    • Studies of Interest
    • Escher Prize
    • Grants
    • Smoking Workshop
    • Webinar Series
    • Parent Survey
  • Presentations
  • About Us
    • Contact
    • Join our Email List
    • Jill Escher Q&A
  • Blog