Archived:
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Webinar 1: "Early Germline Events in the Heritable Etiology of ASDs"

Featuring Amander Clark, PhD, Department of Molecular and Cell Biology, UCLA: "Molecular dynamics and epigenomic vulnerabilities of the early germline in humans"
Ryan Yuen, PhD, Center for Applied Genomics, Hospital for SickKids: "Overview of heterogenous de novo genomic alterations in ASD subjects"
Commentary by Patrick Allard, PhD, Janine LaSalle, PhD, Lisa Chadwick, PhD, and Stephan Sanders, PhD
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Webinar 2: "Environmental Exposures and the Germline: Investigating Causes of Epigenomic and Genomic Errors"

Featuring Dana Dolinoy, PhD, University of Michigan: "Heritable epigenetic effects of germline exposure to toxicants"
Carole Yauk, PhD, Health Canada: "Analysis of chemical exposures and life stage factors that contribute to genetic disease"
Commentary by Cathrine Hoyo, PhD, and Lisa Chadwick, PhD

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Webinar 3: "Special Genes, Special Functions: All About Genomic Imprinting, and Implications for Autism Research"
Wednesday, May 4, 2016
Featuring Christopher Gregg, PhD, Assistant Professor of Neurobiology and Anatomy, Adjunct Assistant Professor of Human Genetics, University of Utah
Overview: Maternally and paternally inherited chromosomes are not functionally equivalent due to heritable epigenetic marks, called genomic imprints. The Gregg Lab has uncovered an array of complex parental effects indicating distinct maternal and paternal gene expression programs in the brain.
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Webinar 4: "The potential role of epigenetics in sex differences in autism"
Tracy Bale, PhD
Professor of Neuroscience in Psychiatry, University of Pennsylvania
Introduction by: Donna Werling, PhD, Postdoctoral Scholar, UCSF
 
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Webinar 5: "Exploiting genetics to identify environmental risks for autism"
Mark Zylka, PhD
Jeffrey Houpt Distinguished Investigator
Director, UNC Neuroscience Center
Professor, Cell Biology & Physiology
With comment by Valerie Hu, PhD, George Washington University.

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Webinar 6: Investigating gene x environment interactions in "single gene autisms"
Janine LaSalle, PhD
Professor, Medical Microbiology and Immunology, UC Davis Genome Center, UC Davis MIND Institute
Commentary by Keith Dunaway, PhD

Latest Expert Q&As

Commentary: Germline mutagenesis: The forgotten realm of public health research

Grandmother's smoking in pregnancy linked to autism in grandchildren

To understand autism, talk to the grandmothers
 
"Time Bomb" Hypothesis of Autism Featured on Autism Speaks Blog

Is Grandmaternal Smoking the Primary Force Behind the Autism Surge?

Is the Autism Surge a "Genetic Emergency" Foreseen by Geneticists in the 1960s?
NeuroTribes: One Step Forward, Two Steps Back for Autism
"NeuroTribes is a phase—some complacency-manifesto-wreckage on the road toward progress in the understanding of this explosion of abnormal neurodevelopment we call autism."

Escher Fund for Autism files FDA petition to withdraw approval for pregnancy drug
The Escher Fund for Autism has spearheaded multiple research projects to examine disruptive germline programming effects of drug, smoking, and chemical exposures.

Past grantees include:
University of Bristol • Child Health and Development Survey • University of Copenhagen • UCSF • Harvard University • UCSD • Rockefeller University • Brown University • UCLA • Autism Speaks • Linkoping University • University of Chicago • Stanford University • Florida State University • North Carolina State University • Colorado State University • Columbia University • Keystone Symposia • Gordon Research Conferences • International Society for Autism Research • Environmental Mutagenesis & Genomics Society • Society of Toxicology • and more

Please join our mailing list to learn the latest about our grants and research activities.
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Jill Escher
on a serendipitous discovery of  medical records and the resulting intergenerational hypothesis.
• In Environmental and Molecular Mutagenesis: Pregnancy drugs, fetal germline epigenome, and risks for next‐generation pathology: A call to action
• In Environmental Epigenetics: Bugs in the Program : can pregnancy drugs and smoking disturb molecular reprogramming of the fetal germline, increasing heritable risk for autism and neurodevelopmental disorders?

Selected presentations and articles
A Thalidomide Daughter Asks, Where's the Long-Term Follow-Up?

My British Parents Smoked Nonstop Whilst I (and My Germ Cells) Were Developing in the Womb—Could this Be What Caused My Son's Autism?
A Father Prenatally Exposed to Synthetic Hormones, a Son with Severe Mental Illness and Autism: Is Germline Epimutation at Work?
A mother of three children with autism speaks out about her own prenatal drug exposures
Germline exposures are now a red-hot topic in science and the media. Check out some of the top stories from the popular press.

Expert Interviews: Learn About Germline, Exposures, and Epigenetics

Find all our expert Q&As here.

Ascertaining Germline Risks of Chemical Exposures with Francesco Marchetti, PhD, and Carole Yauk, PhD, Health Canada
Gene-Environment Interaction in the Etiology of Autism Spectrum Disorder
with Alycia Halladay, PhD, formerly of Autism Speaks
Epigenetics: Evolutionary Theory in Transition
with Professor Eva Jablonka, Tel Aviv University
Prenatal Stressors and Epigenetics in the Development of Behavioral Disorders
with Tracy Bale, PhD, University of Pennsylvania
Epigenetic Effects of Prenatal Alcohol Exposure
with Epigeneticist Ben Laufer, Western University
The Effects of Endocrine Disrupting Chemicals
with Carol Kwiatkowski, PhD, the Endocrine Disruption Exchange
Germline Effects of In Utero Exposure to Nicotine
with Pradeep Bhide, PhD, University of South Florida
How Epigenetics Influences the Risk of Disease
with Susan Murphy, PhD, Duke University
The Role of Epigenetics in Autism Spectrum Disorders
with Janine LaSalle, PhD, UC Davis
What Glowing Worms Teach Us About Germ Cell Toxicity
with Patrick Allard, PhD, UCLA
How Exposures Can Modify the Epigenome
with Dana Dolinoy, PhD, University of Michigan
Effects of Exposures on Development of Oocytes
with Patricia Hunt, PhD, Washington State University
Epigenetics of Human Germline Development
with Amander Clark, PhD, UCLA
How Environmental Factors Change Epigenetics of Germline
with Mirella Meyer-Fica, PhD, University of Utah
Multigenerational Effects of Endocrine-Disrupting Molecules
with Emilie Rissman, PhD, North Carolina State University
Imprinting, Gene Regulation, and Early Development
with Randy Jirtle, PhD, GeneImprint.org
Developmental Origins of Disease
with Jerry Heindel, PhD, NIEHS
Fetal Origins of Disease and the Enduring Impacts of Early-Life Exposures with Carmen Marsit, PhD, Dartmouth Medical School
Dimensions in Autism Genetics
with Wendy Chung, MD, PhD, Columbia University
Environmental Exposures and Our Dynamic Epigenome
with Linda Birnbaum, PhD, NIEHS
Persistent Epigenetic Consequences of Critical-Window Exposures
with Carlos Guerrero-Bosagna, PhD, Linkoping University
New Discoveries in Genomic Imprinting
with Catherine Dulac, PhD, Harvard University
Connecting Exposures to Epigenetic Effects
with Cheryl Walker, PhD, Texas A&M University
Epigenetic Susceptibility: A Source of Environmental Risk
with Andrea Baccarelli, MD, PhD, Harvard University
Germline Effects of Maternal Smoking with Eileen McLaughlin, PhD, University of Newcastle
Genomic Imprinting: Key for Neurodevelopment
with Christopher Gregg, PhD, University of Utah

A Revolution in Germline Toxicology: Dr. Toshi Shioda’s “PGC-LCs”
with Toshi Shioda, PhD, Harvard University
Assisted Fertility and Epigenetic Disruption
with Marisa Bartolomei, PhD, University of Pennsylvania
Non-DNA Mediated Transmission of Behavior Across Generations
with Miklos Toth, MD, Cornell Medical Center
Adverse Multigenerational Effects of Maternal Smoking
with Virender Rehan, MD, UCLA
The Hidden History of Pregnancy Drugs with June Reinisch, PhD, Prenatal Development Project
The Developing Genome
with David Moore, PhD, Pitzer College


Post-war Obstetric Practice with Mark Klebanoff, MD, MPH, University of Ohio
What Causes Genetic Copy Number Variations?
with Lucas Argueso, PhD,
Colorado State University

Chemicals Can Exert Direct Epigenetic Effects on Exposed Fetal Germ Cells with Piroska Szabó, PhD, Van Andel Institute
"DNA is not the sole transmitter of inheritance" with Denis Noble, CBE FRS FRCP FMedSci, Oxford University
This site is sponsored by:
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The Escher Fund for Autism and the Escher Family Fund are donor-advised funds, the former at Schwab Charitable, the latter at Silicon Valley Community Foundation.



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