Archived:
Webinar 1: "Early Germline Events in the Heritable Etiology of ASDs"
Featuring Amander Clark, PhD, Department of Molecular and Cell Biology, UCLA: "Molecular dynamics and epigenomic vulnerabilities of the early germline in humans"
Ryan Yuen, PhD, Center for Applied Genomics, Hospital for SickKids: "Overview of heterogenous de novo genomic alterations in ASD subjects"
Commentary by Patrick Allard, PhD, Janine LaSalle, PhD, Lisa Chadwick, PhD, and Stephan Sanders, PhD
Featuring Amander Clark, PhD, Department of Molecular and Cell Biology, UCLA: "Molecular dynamics and epigenomic vulnerabilities of the early germline in humans"
Ryan Yuen, PhD, Center for Applied Genomics, Hospital for SickKids: "Overview of heterogenous de novo genomic alterations in ASD subjects"
Commentary by Patrick Allard, PhD, Janine LaSalle, PhD, Lisa Chadwick, PhD, and Stephan Sanders, PhD
Webinar 2: "Environmental Exposures and the Germline: Investigating Causes of Epigenomic and Genomic Errors"
Featuring Dana Dolinoy, PhD, University of Michigan: "Heritable epigenetic effects of germline exposure to toxicants"
Carole Yauk, PhD, Health Canada: "Analysis of chemical exposures and life stage factors that contribute to genetic disease"
Commentary by Cathrine Hoyo, PhD, and Lisa Chadwick, PhD
Featuring Dana Dolinoy, PhD, University of Michigan: "Heritable epigenetic effects of germline exposure to toxicants"
Carole Yauk, PhD, Health Canada: "Analysis of chemical exposures and life stage factors that contribute to genetic disease"
Commentary by Cathrine Hoyo, PhD, and Lisa Chadwick, PhD
Webinar 3: "Special Genes, Special Functions: All About Genomic Imprinting, and Implications for Autism Research"
Wednesday, May 4, 2016
Featuring Christopher Gregg, PhD, Assistant Professor of Neurobiology and Anatomy, Adjunct Assistant Professor of Human Genetics, University of Utah
Overview: Maternally and paternally inherited chromosomes are not functionally equivalent due to heritable epigenetic marks, called genomic imprints. The Gregg Lab has uncovered an array of complex parental effects indicating distinct maternal and paternal gene expression programs in the brain.
Wednesday, May 4, 2016
Featuring Christopher Gregg, PhD, Assistant Professor of Neurobiology and Anatomy, Adjunct Assistant Professor of Human Genetics, University of Utah
Overview: Maternally and paternally inherited chromosomes are not functionally equivalent due to heritable epigenetic marks, called genomic imprints. The Gregg Lab has uncovered an array of complex parental effects indicating distinct maternal and paternal gene expression programs in the brain.
Webinar 4: "The potential role of epigenetics in sex differences in autism"
Tracy Bale, PhD
Professor of Neuroscience in Psychiatry, University of Pennsylvania
Introduction by: Donna Werling, PhD, Postdoctoral Scholar, UCSF
Tracy Bale, PhD
Professor of Neuroscience in Psychiatry, University of Pennsylvania
Introduction by: Donna Werling, PhD, Postdoctoral Scholar, UCSF
Webinar 5: "Exploiting genetics to identify environmental risks for autism"
Mark Zylka, PhD
Jeffrey Houpt Distinguished Investigator
Director, UNC Neuroscience Center
Professor, Cell Biology & Physiology
With comment by Valerie Hu, PhD, George Washington University.
Mark Zylka, PhD
Jeffrey Houpt Distinguished Investigator
Director, UNC Neuroscience Center
Professor, Cell Biology & Physiology
With comment by Valerie Hu, PhD, George Washington University.
Webinar 6: Investigating gene x environment interactions in "single gene autisms"
Janine LaSalle, PhD
Professor, Medical Microbiology and Immunology, UC Davis Genome Center, UC Davis MIND Institute
Commentary by Keith Dunaway, PhD
Janine LaSalle, PhD
Professor, Medical Microbiology and Immunology, UC Davis Genome Center, UC Davis MIND Institute
Commentary by Keith Dunaway, PhD
Latest Expert Q&As
- Denis Noble, CBE FRS FRCP FMedSci, Oxford University: "DNA is not the sole transmitter of inheritance."
- Toshi Shioda, MD, PhD, Harvard University: A new way to test for germline toxicity, PGC-LCs
- Piroska Szabó, PhD, Van Andel Institute: Chemicals can exert direct epigenetic effects on exposed fetal germ cells
- Miklos Toth, PhD, Cornell Medical Center: Non-genetic but germ cell-based transmission of traits
- June Reinisch, PhD, Prenatal Development Project: The hidden history of pregnancy drugs (Prenatal Exposures Oral History Project)
- Mark Klebanoff, MD, MPH, University of Ohio: Post-war obstetrics (Prenatal Exposures Oral History Project)
- Lucas Argueso, PhD, Colorado State University: What causes germline de novo copy number variations?
- Patrick Allard, PhD, UCLA: What glowing worms teach us about germline toxicology
- Catherine Dulac, PhD, Harvard University: New discoveries in genomic imprinting
NeuroTribes: One Step Forward, Two Steps Back for Autism
"NeuroTribes is a phase—some complacency-manifesto-wreckage on the road toward progress in the understanding of this explosion of abnormal neurodevelopment we call autism." |
The Escher Fund for Autism has spearheaded multiple research projects to examine disruptive germline programming effects of drug, smoking, and chemical exposures. NEW! 2017 RFA Announced. Details here.
READ THE SPRING 2017 NEWSLETTER Past grantees include: University of Bristol • Child Health and Development Survey • University of Copenhagen • UCSF • Harvard University • UCSD • Rockefeller University • Brown University • UCLA • Autism Speaks • Linkoping University • University of Chicago • Stanford University • Florida State University • North Carolina State University • Colorado State University • Columbia University • Keystone Symposia • Gordon Research Conferences • International Society for Autism Research • Environmental Mutagenesis & Genomics Society • Society of Toxicology • and more Please join our mailing list to learn the latest about our grants and research activities.
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Jill Escher
on a serendipitous discovery of medical records and the resulting autism causation hypothesis. Selected presentations and articles |
Germline exposures are now a red-hot topic in science and the media. Check out some of the top stories (64 and counting!) from the popular press.
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Expert Interviews: Learn About Germline, Exposures, and Epigenetics
Find all our expert Q&As here.
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Ascertaining Germline Risks of Chemical Exposures with Francesco Marchetti, PhD, and Carole Yauk, PhD, Health Canada
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Gene-Environment Interaction in the Etiology of Autism Spectrum Disorder
with Alycia Halladay, PhD, formerly of Autism Speaks |
Epigenetics: Evolutionary Theory in Transition
with Professor Eva Jablonka, Tel Aviv University |
Prenatal Stressors and Epigenetics in the Development of Behavioral Disorders
with Tracy Bale, PhD, University of Pennsylvania |
Epigenetic Effects of Prenatal Alcohol Exposure
with Epigeneticist Ben Laufer, Western University |
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The Effects of Endocrine Disrupting Chemicals
with Carol Kwiatkowski, PhD, the Endocrine Disruption Exchange |
Germline Effects of In Utero Exposure to Nicotine
with Pradeep Bhide, PhD, University of South Florida |
How Epigenetics Influences the Risk of Disease
with Susan Murphy, PhD, Duke University |
The Role of Epigenetics in Autism Spectrum Disorders
with Janine LaSalle, PhD, UC Davis |
What Glowing Worms Teach Us About Germ Cell Toxicity
with Patrick Allard, PhD, UCLA |
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How Exposures Can Modify the Epigenome
with Dana Dolinoy, PhD, University of Michigan |
Effects of Exposures on Development of Oocytes
with Patricia Hunt, PhD, Washington State University |
Epigenetics of Human Germline Development
with Amander Clark, PhD, UCLA |
How Environmental Factors Change Epigenetics of Germline
with Mirella Meyer-Fica, PhD, University of Utah |
Multigenerational Effects of Endocrine-Disrupting Molecules
with Emilie Rissman, PhD, North Carolina State University |
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Imprinting, Gene Regulation, and Early Development
with Randy Jirtle, PhD, GeneImprint.org |
Developmental Origins of Disease
with Jerry Heindel, PhD, NIEHS |
Fetal Origins of Disease and the Enduring Impacts of Early-Life Exposures with Carmen Marsit, PhD, Dartmouth Medical School
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Dimensions in Autism Genetics
with Wendy Chung, MD, PhD, Columbia University |
Environmental Exposures and Our Dynamic Epigenome
with Linda Birnbaum, PhD, NIEHS |
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Persistent Epigenetic Consequences of Critical-Window Exposures
with Carlos Guerrero-Bosagna, PhD, Linkoping University |
Connecting Exposures to Epigenetic Effects
with Cheryl Walker, PhD, Texas A&M University |
Epigenetic Susceptibility: A Source of Environmental Risk
with Andrea Baccarelli, MD, PhD, Harvard University |
Germline Effects of Maternal Smoking with Eileen McLaughlin, PhD, University of Newcastle
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A Revolution in Germline Toxicology: Dr. Toshi Shioda’s “PGC-LCs”
with Toshi Shioda, PhD, Harvard University |
Assisted Fertility and Epigenetic Disruption
with Marisa Bartolomei, PhD, University of Pennsylvania Non-DNA Mediated Transmission of Behavior Across Generations
with Miklos Toth, MD, Cornell Medical Center |
Adverse Multigenerational Effects of Maternal Smoking
with Virender Rehan, MD, UCLA The Hidden History of Pregnancy Drugs with June Reinisch, PhD, Prenatal Development Project
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Post-war Obstetric Practice with Mark Klebanoff, MD, MPH, University of Ohio
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Chemicals Can Exert Direct Epigenetic Effects on Exposed Fetal Germ Cells with Piroska Szabó, PhD, Van Andel Institute
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"DNA is not the sole transmitter of inheritance" with Denis Noble, CBE FRS FRCP FMedSci, Oxford University
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