Environmental stressors such as drugs and smoking can affect the molecular coherence of human germline, that is, the genetic and epigenetic programming contained within our egg and sperm, causing pathology in offspring. We aim to educate the public, researchers, and regulators about this under-appreciated source of risk.
• "Quasi-Genetics" at the Roots of Autism? By LaDonna Ford, MD and Jill Escher
• Bugs in the Program: why non-genetic inheritance should be a priority in autism research. By Jill Escher [In Environmental Epigenetics journal]
• Pregnancy Drugs, Fetal Germline Epigenome, and Risks for Next-Generation Pathology: A Call to Action. By Jill Escher and Suzanne Robotti [in Environmental and Molecular Mutagenesis journal]
• 100+ studies demonstrating nongenetic inheritance in mammals and humans
• Nomination of germ cell impacts of general anesthetic gases to National Toxicology Program
• Nomination for OHAT scoping review of human and mammal evidence for adverse heritable impacts of direct germ cell exposure to drugs and chemicals
• Request for NIH research program on the heritable effects of general anesthesia