Germline Exposures
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Heritable Hazards of Smoking Workshop, September 19, 2019

4/12/2019

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View the videotaped presentations in this YouTube playlist

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Smoking for three: pregnancy smoking can affect early germ cells developing within the embryo and fetus. Other periods of germline vulnerability will also be discussed at the workshop.
Environmental Mutagenesis and Genomics Society Conference, Heritable Hazards of Smoking Workshop
September 19, 2019, 8:45am to 3.30pm
Washington, DC

Abstract
: Mounting evidence indicates that toxicant exposures to germ cells can impair the health and development of offspring in a variety of ways.  Despite this, today’s regulatory paradigms focus on somatic impacts, with little consideration for the perturbation of the genetic and epigenetic features of germ cells or the heritable consequences thereof. This workshop will use the example of tobacco smoke as a case study to apply a modern next-generation testing paradigm, i.e., the Clean Sheet approach, in which we will encompass both somatic and germinal genomic damage in human risk assessment [Dearfield et al., Next Generation Testing Strategy for Assessment of Genomic Damage: A Conceptual Framework and Considerations. Environ Mol Mutagen 58:264-283, 2017].  The workshop consists of four parts: (1) background information about the Clean Sheet Initiative, tobacco toxicity, and germline vulnerabilities; (2) overview of evidence for germline impacts in humans and other mammals; (3) regulatory perspective; and (4) discussion geared toward consensus regarding needs for research and regulation.
​
Webpage: 
https://www.emgs-us.org/p/cm/ld/fid=394
Registration: www.emgs-us.org/p/cm/ld/fid=386
Co-Chairs: Francesco Marchetti, Health Canada, Jill Escher, Escher Fund for Autism

Organizing Committee: Abigail Bline, UCLA, Kerry Dearfield, Retired (formerly at USDA and EPA), David DeMarini, US EPA, Jill Escher, Francesco Marchetti, Carole Yauk, Health Canada

8:45-9:00 AM
Welcome, Opening Remarks, and Introductions
Jill Escher, Escher Fund for Autism


9:00-9:20 AM
The Clean Sheet Initiative and Its Potential to Identify the Risks of Heritable Consequences of Tobacco Smoke Exposures
Kerry L. Dearfield, Retired (formerly at USDA and EPA), Burke, VA


9:20-9:40 AM
Rationale for This Workshop: Growing Concern Regarding Heritable and Intergenerational Effects from Environmental Exposures 
Carole L. Yauk, Health Canada


9:40-10:00 AM
The Potentially Vulnerable Periods of Exposure to the Male and Female Germline 
Jacquetta Trasler, McGill University, Montreal, ON, Canada


10:00-10:20 AM
Coffee Break


10:20-10:40 AM
Tobacco Smoke Exposure: Hazardous Components of Tobacco and Related products; Broad Overview of Known Health Effects; Tobacco-Induced Male Germ Cell and Heritable Effects
Francesco Marchetti, Health Canada


10:40-11:00 AM
Male-Mediated Heritable Epigenetic Effects 
Jacquetta Trasler, McGill University, Montreal, ON, Canada


11:00-11:20 AM
Overview of Asthma and Allergy Epidemiology: Epigenetic Studies of Transgenerational Effects of Smoking
John Holloway, University of Southhampton, UK


11:20-11:40 AM
Multigenerational Transmission of Hyperactivity/ADHD
Pradeep Bhide, Florida State University, Tallahassee, FL, USA


11:40-11:50
Grandmaternal Smoking and Risk for ADHD
Gyeyoon Yim, ScD candidate, Harvard T.H. Chan School of Public Health, MA, USA


11:50-12:10 PM
The RHINESSA Cohort, a Three-Generation Study on the Association of Tobacco Smoking with Asthma 
Cecillie Svanes, University of Bergen, Norway

12:10-12:30 PM
Panel Discussion of the Evidence

12:30-1:30 PM
Lunch (provided)

1:30-2:00 PM
Toxicology of E-cigarettes
Ilona Jaspers, University of North Carolina, NC, USA


2:00-2:30 PM
Discussants
Implications for Bioethics
Anne Le Goff, Institute for Society and Genetics, UCLA, CA, USA
Implications for Public Health Advocacy
Laurent Huber, Executive Director, ASH, Washington, DC, USA
​

2:30-3:30 PM
Directed Discussion and Consensus Opinion 
Methods and data to study intergenerational effects of these products and how to apply the Clean Sheet Framework. Is there a need for regulatory policy to emphasize germ cell risk in addition to somatic cell risk? Next steps?
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    Author

    Jill Escher, Escher Fund for Autism, is a California-based science philanthropist and mother of two children with severe autism, focused on the question of how environmentally induced germline disruptions may be contributing to today's epidemics of neurodevelopmental impairment. You can read about her discovery of her intensive prenatal exposure to synthetic hormone drugs here. Jill is also president of Autism Society San Francisco Bay Area.

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  • Home
  • Expert Q&A
    • Eva Jablonka Q&A
    • Amander Clark Q&A
    • Mirella Meyer-Ficca Q&A
    • Janine LaSalle Q&A
    • Dana Dolinoy Q&A
    • Ben Laufer Q&A
    • Tracy Bale Q&A
    • Susan Murphy Q&A
    • Alycia Halladay Q&A
    • Wendy Chung Q&A
    • Pradeep Bhide Q&A
    • Pat Hunt Q&A
    • Yauk and Marchetti Q&A
    • Emilie Rissman Q&A
    • Carol Kwiatkowski Q&A
    • Linda Birnbaum Q&A
    • Virender Rehan Q&A
    • Carlos Guerrero-Bosagna Q&A
    • Randy Jirtle Q&A
    • Jerry Heindel Q&A
    • Cheryl Walker Q&A
    • Eileen McLaughlin Q&A
    • Carmen Marsit Q&A
    • Marisa Bartolomei Q&A
    • Christopher Gregg Q&A
    • Andrea Baccarelli Q&A
    • David Moore Q&A
    • Patrick Allard Q&A
    • Catherine Dulac Q&A
    • Lucas Argueso Q&A
    • Toshi Shioda Q&A
    • Miklos Toth Q&A
    • Piroska Szabo Q&A
    • Reinisch Q&A
    • Klebanoff Q&A
    • Denis Noble Q&A
  • Germline in the News
  • Science
    • Studies of Interest
    • Escher Prize
    • Grants
    • Smoking Workshop
    • Webinar Series
    • Parent Survey
  • Presentations
  • About Us
    • Contact
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