  Smoking for three: pregnancy smoking can affect early germ cells developing within the embryo and fetus. Other periods of germline vulnerability will also be discussed at the workshop. Environmental Mutagenesis and Genomics Society Conference, Heritable Hazards of Smoking Workshop September 19, 2019, 8:45am to 3.30pm Washington, DC Abstract: Mounting evidence indicates that toxicant exposures to germ cells can impair the health and development of offspring in a variety of ways. Despite this, today’s regulatory paradigms focus on somatic impacts, with little consideration for the perturbation of the genetic and epigenetic features of germ cells or the heritable consequences thereof. This workshop will use the example of tobacco smoke as a case study to apply a modern next-generation testing paradigm, i.e., the Clean Sheet approach, in which we will encompass both somatic and germinal genomic damage in human risk assessment [Dearfield et al., Next Generation Testing Strategy for Assessment of Genomic Damage: A Conceptual Framework and Considerations. Environ Mol Mutagen 58:264-283, 2017]. The workshop consists of four parts: (1) background information about the Clean Sheet Initiative, tobacco toxicity, and germline vulnerabilities; (2) overview of evidence for germline impacts in humans and other mammals; (3) regulatory perspective; and (4) discussion geared toward consensus regarding needs for research and regulation. Webpage: https://www.emgs-us.org/p/cm/ld/fid=394 Registration: www.emgs-us.org/p/cm/ld/fid=386 Co-Chairs: Francesco Marchetti, Health Canada, Jill Escher, Escher Fund for Autism
Organizing Committee: Abigail Bline, UCLA, Kerry Dearfield, Retired (formerly at USDA and EPA), David DeMarini, US EPA, Jill Escher, Francesco Marchetti, Carole Yauk, Health Canada 8:45-9:00 AM Welcome, Opening Remarks, and Introductions Jill Escher, Escher Fund for Autism 9:00-9:20 AM The Clean Sheet Initiative and Its Potential to Identify the Risks of Heritable Consequences of Tobacco Smoke Exposures Kerry L. Dearfield, Retired (formerly at USDA and EPA), Burke, VA 9:20-9:40 AM Rationale for This Workshop: Growing Concern Regarding Heritable and Intergenerational Effects from Environmental Exposures Carole L. Yauk, Health Canada 9:40-10:00 AM The Potentially Vulnerable Periods of Exposure to the Male and Female Germline Jacquetta Trasler, McGill University, Montreal, ON, Canada 10:00-10:20 AM Coffee Break 10:20-10:40 AM Tobacco Smoke Exposure: Hazardous Components of Tobacco and Related products; Broad Overview of Known Health Effects; Tobacco-Induced Male Germ Cell and Heritable Effects Francesco Marchetti, Health Canada 10:40-11:00 AM Male-Mediated Heritable Epigenetic Effects Jacquetta Trasler, McGill University, Montreal, ON, Canada 11:00-11:20 AM Overview of Asthma and Allergy Epidemiology: Epigenetic Studies of Transgenerational Effects of Smoking John Holloway, University of Southhampton, UK 11:20-11:40 AM Multigenerational Transmission of Hyperactivity/ADHD Pradeep Bhide, Florida State University, Tallahassee, FL, USA 11:40-11:50 Grandmaternal Smoking and Risk for ADHD Gyeyoon Yim, ScD candidate, Harvard T.H. Chan School of Public Health, MA, USA 11:50-12:10 PM The RHINESSA Cohort, a Three-Generation Study on the Association of Tobacco Smoking with Asthma Cecillie Svanes, University of Bergen, Norway 12:10-12:30 PM Panel Discussion of the Evidence 12:30-1:30 PM Lunch (provided) 1:30-2:00 PM Toxicology of E-cigarettes Ilona Jaspers, University of North Carolina, NC, USA 2:00-2:30 PM Discussants Implications for Bioethics Anne Le Goff, Institute for Society and Genetics, UCLA, CA, USA Implications for Public Health Advocacy Laurent Huber, Executive Director, ASH, Washington, DC, USA 2:30-3:30 PM Directed Discussion and Consensus Opinion Methods and data to study intergenerational effects of these products and how to apply the Clean Sheet Framework. Is there a need for regulatory policy to emphasize germ cell risk in addition to somatic cell risk? Next steps?
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AuthorJill Escher, Escher Fund for Autism, is a California-based science philanthropist and mother of two children with severe autism, focused on the question of how environmentally induced germline disruptions may be contributing to today's epidemics of neurodevelopmental impairment. You can read about her discovery of her intensive prenatal exposure to synthetic hormone drugs here. Jill is also president of Autism Society San Francisco Bay Area. Archives
June 2019
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