Webinars
Webinar 1: "Early Germline Events in the Heritable Etiology of ASDs"
Featuring Amander Clark, PhD, Department of Molecular and Cell Biology, UCLA: "Molecular dynamics and epigenomic vulnerabilities of the early germline in humans"
Ryan Yuen, PhD, Center for Applied Genomics, Hospital for SickKids: "Overview of heterogenous de novo genomic alterations in ASD subjects"
Commentary by Patrick Allard, PhD, Janine LaSalle, PhD, Lisa Chadwick, PhD, and Stephan Sanders, PhD
Featuring Amander Clark, PhD, Department of Molecular and Cell Biology, UCLA: "Molecular dynamics and epigenomic vulnerabilities of the early germline in humans"
Ryan Yuen, PhD, Center for Applied Genomics, Hospital for SickKids: "Overview of heterogenous de novo genomic alterations in ASD subjects"
Commentary by Patrick Allard, PhD, Janine LaSalle, PhD, Lisa Chadwick, PhD, and Stephan Sanders, PhD
Webinar 2: "Environmental Exposures and the Germline: Investigating Causes of Epigenomic and Genomic Errors"
Featuring Dana Dolinoy, PhD, University of Michigan: "Heritable epigenetic effects of germline exposure to toxicants"
Carole Yauk, PhD, Health Canada: "Analysis of chemical exposures and life stage factors that contribute to genetic disease"
Commentary by Cathrine Hoyo, PhD, and Lisa Chadwick, PhD
Webinar 3: On Genomic Imprinting, with Christopher Gregg, PhD, coming May 4, 2016
Featuring Dana Dolinoy, PhD, University of Michigan: "Heritable epigenetic effects of germline exposure to toxicants"
Carole Yauk, PhD, Health Canada: "Analysis of chemical exposures and life stage factors that contribute to genetic disease"
Commentary by Cathrine Hoyo, PhD, and Lisa Chadwick, PhD
Webinar 3: On Genomic Imprinting, with Christopher Gregg, PhD, coming May 4, 2016
Websites and Presentations
Environmental Epigenetics: New Frontiers in Autism Research 2013 symposium list of papers, reviews and commentaries on environmental epigenetics.
• Video presentations from symposium (scroll down)
Environmental Mutagenesis and Genomics Society website
Genetic Science Learning Center: Epigenetics website
GeneImprint.org The Genomic Imprinting website
Presentation on Developmental Programming, by Dr. Cheryl Walker
Epigenetics 101: How Exposure to Environmental Toxicants Alters Gene Expression and the Development of Disease with Dr. Cheryl Walker and Dr. Michael Skinner
• Video presentations from symposium (scroll down)
Environmental Mutagenesis and Genomics Society website
Genetic Science Learning Center: Epigenetics website
GeneImprint.org The Genomic Imprinting website
Presentation on Developmental Programming, by Dr. Cheryl Walker
Epigenetics 101: How Exposure to Environmental Toxicants Alters Gene Expression and the Development of Disease with Dr. Cheryl Walker and Dr. Michael Skinner
Research Papers Relating to Germline, Epigenetics, Intergenerational Transmission and Related Themes in Autism Spectrum Disorders
Poor maternal ovary health (PCOS) or poor paternal /sperm health associated with ASD risk:
ASD risk associated with epigenetic changes in fathers’ sperm (Feinberg 2015)
PCOS mothers more likely to have daughters with PDDs (Palomba 2012)
PCOS mothers more likely to have children with ASD (Kosidou 2015)
Paternal obesity associated with increased risk of ASD in offspring (Suren 2014)
Advanced paternal age associated with ASD risk (many)
Epigenetic differences seen in ASD subjects:
Methylation differences in twins discordant for ASD (Mill 2013)
Methylation differences in post-mortem ASD brains (Ladd-Acosta 2013)
ASD brains had more genes up- or down-regulated in an individual-specific manner (Ben-David 2014)
Methylation differences in ectodermal cells of ASD children born to older mothers (Berko 2014)
Review: Epigenomic strategies at the interface of genetic and environmental risk factors for autism (LaSalle 2013)
Grandparental age associated with ASD risk:
Older grandmothers associated with risk of ASD (Golding 2010)
Father born to older fathers associated with risk of ASD in offspring (Frans 2013)
Multigenerational adverse behavioral outcomes in animal models Induced by gestational exposure to toxicants (examples)
Epigenetic transgenerational inheritance of altered stress responses (Crews 2012)
Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression (Wolstenholme 2012)
Transgenerational transmission and modification of pathological traits induced by prenatal immune activation (Weber-Stadlbauer 2016)
ASD risk associated with epigenetic changes in fathers’ sperm (Feinberg 2015)
PCOS mothers more likely to have daughters with PDDs (Palomba 2012)
PCOS mothers more likely to have children with ASD (Kosidou 2015)
Paternal obesity associated with increased risk of ASD in offspring (Suren 2014)
Advanced paternal age associated with ASD risk (many)
Epigenetic differences seen in ASD subjects:
Methylation differences in twins discordant for ASD (Mill 2013)
Methylation differences in post-mortem ASD brains (Ladd-Acosta 2013)
ASD brains had more genes up- or down-regulated in an individual-specific manner (Ben-David 2014)
Methylation differences in ectodermal cells of ASD children born to older mothers (Berko 2014)
Review: Epigenomic strategies at the interface of genetic and environmental risk factors for autism (LaSalle 2013)
Grandparental age associated with ASD risk:
Older grandmothers associated with risk of ASD (Golding 2010)
Father born to older fathers associated with risk of ASD in offspring (Frans 2013)
Multigenerational adverse behavioral outcomes in animal models Induced by gestational exposure to toxicants (examples)
Epigenetic transgenerational inheritance of altered stress responses (Crews 2012)
Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression (Wolstenholme 2012)
Transgenerational transmission and modification of pathological traits induced by prenatal immune activation (Weber-Stadlbauer 2016)